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The biology of aging is still largely a mystery. Researchers are working hard to unravel the molecular and cellular causes of aging and to find ways to prevent age-related diseases. These discoveries, and the science that may help people stay healthy as they age, are reported here.

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27.10.2025

Study shows that a decline in wellbeing in old age is not inevitable

Study shows that a decline in wellbeing in old age is not inevitable

A Canadian study shows that a decline in well-being in old age is not inevitable, as many older adults are able to regain full performance.

Quelle

Reclaiming wellness: Key factors in restoring optimal well-being in the Canadian Longitudinal Study on Aging” by Mabel Ho and Esme Fuller-Thomson, September 24, 2025, PLOS ONE. DOI: 10.1371/journal.pone.0329800

9.10.2025

Ubiquitin precursor promotes stress resistance and longevity

Ubiquitin precursor promotes stress resistance and longevity

Researchers from the University of Cologne and Heinrich Heine University Düsseldorf have identified a new form of the protein ubiquitin, which is responsible for proteostasis, i.e. protein balance, and healthy aging. The study shows that ubiquitin, which is extended at the end (CxUb), contributes to the stress resistance of cells. This discovery opens up potentially new perspectives for the treatment of cancer and age-related diseases.

Quelle

Altin, Selver et al., Molecular Cell, Volume 85, Issue 19, 3677 - 3693.e7

5.10.2025

Vitamin D May Slow Aging, According to a Study

Vitamin D May Slow Aging, According to a Study

A new study suggests that vitamin D may protect the sensitive chromosome caps associated with aging, potentially reducing the risk of age-related diseases.

Quelle

“Vitamin D3 and marine ω-3 fatty acids supplementation and leucocyte telomere length: 4-year findings from the Vitamine D and Omega-3 trial (VITAL) randomized controlled trial” by Haidong Zhu, JoAnn E Manson, Nancy R Cook, Bayu B Bekele, Li Chen, Kevin J Kane, Ying Huang, Wenjun Li, William Christen, I-Min Lee and Yanbin Dong, 21 May 2025, The American Journal of Clinical Nutrition. DOI: 10.1016/j.ajcnut.2025.05.003

21.9.2025

Scientists discover hidden drivers of aging that can potentially be reversed

Scientists discover hidden drivers of aging that can potentially be reversed

A drop in the protein menin in the brain's hypothalamus appears to be a major factor in aging by triggering inflammation and loss of important neurotransmitters. Mouse studies show that restoring menin or supplementing with the amino acid D-serine improves cognitive abilities, bone density, skin thickness, and balance — suggesting a potential way to slow or even reverse aspects of aging.

Quelle

Leng L, Yuan Z, Su X, Chen Z, Yang S, Chen M, et al. (2023) Hypothalamic menin regulates systemic aging and cognitive decline. PLoS Biol 21 (3): e3002033. https://doi.org/10.1371/journal.pbio.3002033

21.9.2025

New biomarker could identify Alzheimer's years before symptoms occur

New biomarker could identify Alzheimer's years before symptoms occur

A new study suggests that TSPO, a key biomarker of inflammation in the brain, can identify the earliest stages of Alzheimer's disease long before symptoms occur.

Quelle

Martinez-Perez, D. A., McGlothan, J. L., Rodichkin, A. N. et al. Amyloid-β plaque-associated microglia drive TSPO upregulation in Alzheimer's disease. Acta Neuropathol 150, 6 (2025). https://doi.org/10.1007/s00401-025-02912-4

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SCIENCE.

EXPLAINED

Aging

Telomeres shorten over the course of a lifetime. The normal aging process is thought to be affected by telomere shortening and thus associated with the onset of disease and increased mortality in old age.

Length

Telomeres are protective caps at the ends of chromosomes that shorten each time a cell divides. When they become so short that the genes they protect could be damaged, cells stop dividing and renewing themselves. As a result, the cells are no longer able to perform their functions. This is thought to be one of the mechanisms of aging.

Function

Telomeres are protective caps at the ends of chromosomes that shorten each time a cell divides. When they become so short that the genes they protect could be damaged, cells stop dividing and renewing themselves. As a result, the cells become less able to perform their functions. This is thought to be one of the mechanisms of aging.

Through prevention and proactive measures. Eating habits: high consumption of meat (especially red meat), a generally fatty diet and obesity cause the chromosome caps to wear down, as does excessive alcohol consumption. Consumption of vegetable products protects the cells.
Physical activity: Interval and endurance training can lengthen telomeres

Protetion

science.
Explained

What are telomeres?

Are these tiny segments of DNA the key to aging?

3D-Render von einem Telomer
George Church, amerikanischer Genetiker
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Science.
Quote

The goal of a genome analysis is not to find out what you will die of, but rather to learn how to prevent diseases from occurring.

George Church

American geneticist, molecular engineer, chemist, and "founder of genomics"

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