Science
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The biology of aging is still largely a mystery. Researchers are working hard to unravel the molecular and cellular causes of aging and to find ways to prevent age-related diseases. These discoveries, and the science that may help people stay healthy as they age, are reported here.
SCIENCE.
NEWS
18.3.2025
New protein discovery could be key to healthier aging
News
March 18, 2025
News
March 18, 2025

New protein discovery could be key to healthier aging
Scientists at McMaster University have made a breakthrough discovery about the protein MANF, which plays a crucial role in cell health and aging. MANF supports cell purification by preventing the formation of toxic proteins that can lead to neurodegenerative diseases such as Alzheimer's and Parkinson's.
Quelle
S.K.B. Taylor, J.H. Hartman, & B.P. Gupta, The neurotrophic factor MANF regulates autophagy and lysosome function to promote proteostasis in Caenorhabditis elegans, Proc. Natl. Acad. Sci. United States 121 (43) e2403906121, https://doi.org/10.1073/pnas.2403906121 (2024)
14.3.2025
New therapies to stimulate bone growth
News
March 18, 2025
News
March 18, 2025
New therapies to stimulate bone growth
Researchers at ETH Zurich have presented high-resolution spatial data on gene activity in bone cells for the first time. They thus show that mechanical stimuli influence the activity of genes in bones. Such stimuli could therefore be used specifically for therapeutic applications. The results could pave the way for new therapeutic approaches against bone loss and for faster bone healing after bone fractures.
Quelle
Neashan Mathavan et al. , Spatial transcriptomics in bone mechanomics: Exploring the mechanoregulation of fracture healing in the era of spatial omics.sci. Adv.11, eadp8496 (2025) .doi:10.1126/sciadv.adp8496
10.2.2025
Alzheimer's biomarker test can detect disease years before onset
News
February 10, 2025
News
February 10, 2025
Alzheimer's biomarker test can detect disease years before onset
Researchers have developed a biomarker test for Alzheimer's disease that can detect tau protein, which tends to clump, and its misfolded pathological forms in brain scans, possibly years before the neurofibrillary tangles occur.
Quelle
Islam, T., Hill, E., Abrahamson, E. E. et al. Phospho-tau serine-262 and serine-356 as biomarkers of pre-tangle soluble tau assemblies in Alzheimer's disease. Nat Med (2025). https://doi.org/10.1038/s41591-024-03400-0
10.2.2025
Daily omega-3 supplementation and regular exercise may slow the aging process
News
February 10, 2025
News
February 10, 2025
Daily omega-3 supplementation and regular exercise may slow the aging process
A new study suggests that omega-3 and vitamin D supplements combined with regular physical exercise may help slow down the biological aging process by several months over a period of three years.
Quelle
Bischoff-Ferrari, H.A., Gägler, S., Wieczorek, M. et al. Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial. Nat Aging (2025). https://doi.org/10.1038/s43587-024-00793-y
12.1.2025
Scientists uncover mitochondrial key
News
January 12, 2025
News
January 12, 2025
Scientists uncover mitochondrial key
New research shows that E-TCmito is an important link between neuronal activity and mitochondrial function, highlighting its potential to counteract cognitive decline in old age and in diseases such as Alzheimer's.
Quelle
Wenwen Li, Jiarui Li, Jing Li, Chen Wei, Tal Laviv, Meiyi Dong, Jingran Lin, Mariah Calubag, Lesley A Colgan, Kai Jin, Bing Zhou, Ying Shen, Haohong Li, Yihui Cui, Zhihua Gao, Hailan Hu, Ryohei Yasuda and Huan Ma, 20 December 2024, Science.
SCIENCE.
EXPLAINED

Science.
Quote
The goal of a genome analysis is not to find out what you will die of, but rather to learn how to prevent diseases from occurring.
George Church
American geneticist, molecular engineer, chemist, and "founder of genomics"