Science
ABOUT science
The biology of aging is still largely a mystery. Researchers are working hard to unravel the molecular and cellular causes of aging and to find ways to prevent age-related diseases. These discoveries, and the science that may help people stay healthy as they age, are reported here.
SCIENCE.
NEWS
31.12.2025
Researchers discover new type of DNA damage hidden in mitochondria
News
January 5, 2026
News
January 5, 2026
Researchers discover new type of DNA damage hidden in mitochondria
Scientists have discovered a previously unknown form of mitochondrial DNA damage. The newly identified “sticky” DNA markers accumulate much more in mitochondrial DNA than in nuclear DNA, causing them to change energy production and trigger cellular defense mechanisms.
Quelle
Y. H. Chen, M. Esparza Sanchez, T.I. Hung, J. Tang, W. Xu, J. Yin, Wang, C.A. Chang, H. Zhang, J. Chen, & L. Zhao, Glutathionylated DNA adducts accumulate in mitochondrial DNA and are regulated by AP endonuclease 1 and tyrosyl-DNA phosphodiesterase 1, Proc. Natl. Acad. Sci. United States 122 (47) e2509312122, https://doi.org/10.1073/pnas.2509312122 (2025).
18.12.2025
Scientists Discover a Way to Recharge Aging Cells
News
December 29, 2025
News
December 29, 2025
Scientists Discover a Way to Recharge Aging Cells
Researchers at Texas A&M University have found a way to revive tired or damaged cells by giving them a fresh supply of mitochondria, the tiny structures that power cellular life.
Quelle
Nanomaterial-induced mitochondrial biogenesis enhances intercellular mitochondrial transfer efficiency” by John Soukar, Kanwar Abhay Singh, Ari Aviles, Sarah Hargett, Harman Kaur, Samantha Foster, Shounak Roy, Feng Zhao, Vishal M. Gohil, Irtisha Singh and Akhilesh K. Gaharwar, 24 October 2025, Proceedings of the National Academy of Sciences.
11.12.2025
The key molecule responsible for the anti-aging effect of sport
News
December 16, 2025
News
December 16, 2025
The key molecule responsible for the anti-aging effect of sport
Systematic molecular blueprint of how exercise reshapes human homeostasis Repeated exercise boosts circulating betaine partly via renal synthesis Betaine inhibits TBK1, reducing senescence and inflammation Betaine exerts multi-organ geroprotection in aged mice
Quelle
Systematic profiling reveals betaine as an exercise mimetic for geroprotection Geng, Lingling et al. Cell, Volume 188, Issue 19, 5403 - 5425.e33
6.12.2025
Super-centenarian gene should delay the onset of aging diseases
News
December 16, 2025
News
December 16, 2025
Super-centenarian gene should delay the onset of aging diseases
Scientists have discovered that a “longevity gene” found in people over 100 years of age can protect the heart from the effects of Progeria, a rare genetic condition that causes premature aging in children.
Quelle
“A longevity-associated variant of the human BPIFB4 gene prevents diastolic dysfunction in progeria mice” by Yan Qiu, Monica Cattaneo, Anna Maciag, Annibale A. Puca and Paolo Madeddu, September 29, 2025, Signal Transduction and Targeted Therapy. DOI: 10.1038/s41392-025-02416-3
6.11.2025
New immune cells discovered that could slow down aging
News
November 10, 2025
News
November 10, 2025
New immune cells discovered that could slow down aging
Researchers have identified a special type of T-helper cell that increases with age and helps eliminate aging cells in the body. This discovery could open up new ways to slow down the aging process and extend healthy life years.
Quelle
“CD4 T cells acquire eomesodermine to modulate cellular senescence and aging” by Yehezqel Elyahu, Ilana Feygin, Ekaterina Eremenko, Noa Pinkas, Alon Zemer, Amit Shicht, Omer Berner, Roni Avigdory-Meiri, Anna Nemirovsky, Keren Reshef, Lior Roitman, Valery Krizhanovsky and Alon Monsonego, October 7, 2025, Nature Aging. DOI: 10.1038/s43587-025-00953-8
SCIENCE.
EXPLAINED
Aging
Alterung
Telomeres shorten over the course of a lifetime. The normal aging process is thought to be affected by telomere shortening and thus associated with the onset of disease and increased mortality in old age.
Length
Länge
Telomeres are protective caps at the ends of chromosomes that shorten each time a cell divides. When they become so short that the genes they protect could be damaged, cells stop dividing and renewing themselves. As a result, the cells are no longer able to perform their functions. This is thought to be one of the mechanisms of aging.
Function
Funktion
Telomeres are protective caps at the ends of chromosomes that shorten each time a cell divides. When they become so short that the genes they protect could be damaged, cells stop dividing and renewing themselves. As a result, the cells become less able to perform their functions. This is thought to be one of the mechanisms of aging.
Schutz
Through prevention and proactive measures. Eating habits: high consumption of meat (especially red meat), a generally fatty diet and obesity cause the chromosome caps to wear down, as does excessive alcohol consumption. Consumption of vegetable products protects the cells.
Physical activity: Interval and endurance training can lengthen telomeres
Protetion
Science.
Quote
The goal of a genome analysis is not to find out what you will die of, but rather to learn how to prevent diseases from occurring.
George Church
American geneticist, molecular engineer, chemist, and "founder of genomics"
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