Science
ABOUT science
The biology of aging is still largely a mystery. Researchers are working hard to unravel the molecular and cellular causes of aging and to find ways to prevent age-related diseases. These discoveries, and the science that may help people stay healthy as they age, are reported here.
SCIENCE.
NEWS
1.5.2024
Switching a diet from beef to seafood could prevent thousands of deaths
News
May 1, 2024
News
May 1, 2024
Switching a diet from beef to seafood could prevent thousands of deaths
A recent study has examined the potential national and global health benefits of replacing red meat with forage fish such as anchovies, herring, and sardines. The results show that replacing red meat with forage fish could prevent up to 750,000 deaths by 2050 and reduce the number of disabilities caused by diet-related diseases.
Quelle
Xia S, Takakura J, Tsuchiya K, et al Unlocking the potential of forage fish to reduce the global burden of disease BMJ Global Health 2024; 9:e013511.
1.5.2024
Parkinson's disease: Intensive physical activity increases levels of dopamine transporters and neuromelanin
News
May 1, 2024
News
May 1, 2024
Parkinson's disease: Intensive physical activity increases levels of dopamine transporters and neuromelanin
A new pilot study suggests that high-intensity physical activity may have a protective effect on the brain that can not only slow down neurodegeneration associated with Parkinson's disease, but may even reverse it.
Quelle
Intense exercise increases dopamine transporter and neuromelanin concentrations in the substantia nigra in Parkinson's disease” by Bart de Laat, Jocelyn Hoye, Gelsina Stanley, Michelle Hespeler, Jennifer Ligi, Varsha Mohan, Dustin W. Wooten, Xiaomeng Zhang, Thanh D. Nguyen, Jose Key, Giulia Colonna, Yiyun Huang, Nabeel Nabulsi, Amar Patel, David Matuskey, Evan D. Morris and Sule Tinaz, February 9, 2024, npj Parkinson's Disease. DOI: 10.1038/s41531-024-00641-1
26.4.2024
Life expectancy predicted by epigenetic age measurements
News
April 26, 2024
News
April 26, 2024
Life expectancy predicted by epigenetic age measurements
A new study funded by the National Institute on Aging underlines the important contribution of biological age watches to the science of longevity. The researchers analyzed data from more than 3,500 participants aged 51 years and older to determine the link between epigenetic aging and age-related health outcomes. They found that second and third generation epigenetic clocks (GrimAge, PhenoAge, DunedInPace) consistently predicted health outcomes including cognitive impairment, functional limitations, chronic diseases, and mortality. According to NIA, the results of the study suggest that, in addition to traditional social and behavioral predictors of health, epigenetic age measurements are a valuable tool for aging research and predicting health outcomes later in life.
Quelle
Faul JD, et al. Epigenetic-based age acceleration in a representative sample of older Americans: Associations with aging-related morbidity and mortality. Proceedings of the National Academy of Sciences of the United States of America. 2023; 120 (23) :e2215840120. doi: 10.1073/pnas.2215840120.
26.4.2024
Air pollution linked to faster cognitive ageing in population study
News
April 26, 2024
News
April 26, 2024
Air pollution linked to faster cognitive ageing in population study
A number of large epidemiological studies have shown that long-term exposure to increased air pollution accelerates the onset and progression of age-related diseases. As a mechanism, it is assumed that particulate matter causes increased chronic inflammation through its interaction with the lungs and other tissues, which in turn contributes to cell and tissue dysfunction that leads to age-related diseases.
Quelle
Wood, D., Evangelopoulos, D., Beevers, S. et al. Exposure to ambient air pollution and cognitive function: an analysis of the English Longitudinal Study of Ageing Cohort.Environ Health 23, 35 (2024). https://doi.org/10.1186/s12940-024-01075-1
26.4.2024
AI-based method speeds up Parkinson's drug discovery 10-fold
News
April 26, 2024
News
April 26, 2024
AI-based method speeds up Parkinson's drug discovery 10-fold
Researchers at Cambridge University have used the power of artificial intelligence (AI) to accelerate the search for new drugs to treat Parkinson's disease.
Quelle
Horne, R. I., Andrzejewska, E. A., Alam, P. et al. Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01580-x
SCIENCE.
EXPLAINED
Aging
Alterung
Telomeres shorten over the course of a lifetime. The normal aging process is thought to be affected by telomere shortening and thus associated with the onset of disease and increased mortality in old age.
Length
Länge
Telomeres are protective caps at the ends of chromosomes that shorten each time a cell divides. When they become so short that the genes they protect could be damaged, cells stop dividing and renewing themselves. As a result, the cells are no longer able to perform their functions. This is thought to be one of the mechanisms of aging.
Function
Funktion
Telomeres are protective caps at the ends of chromosomes that shorten each time a cell divides. When they become so short that the genes they protect could be damaged, cells stop dividing and renewing themselves. As a result, the cells become less able to perform their functions. This is thought to be one of the mechanisms of aging.
Schutz
Through prevention and proactive measures. Eating habits: high consumption of meat (especially red meat), a generally fatty diet and obesity cause the chromosome caps to wear down, as does excessive alcohol consumption. Consumption of vegetable products protects the cells.
Physical activity: Interval and endurance training can lengthen telomeres
Protetion
Science.
Quote
The goal of a genome analysis is not to find out what you will die of, but rather to learn how to prevent diseases from occurring.
George Church
American geneticist, molecular engineer, chemist, and "founder of genomics"
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