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The biology of aging is still largely a mystery. Researchers are working hard to unravel the molecular and cellular causes of aging and to find ways to prevent age-related diseases. These discoveries, and the science that may help people stay healthy as they age, are reported here.

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14.6.2024

Global Research Program Launched to Deploy Blood Biomarker Testing of Alzheimer’s Disease

Global Research Program Launched to Deploy Blood Biomarker Testing of Alzheimer’s Disease

The Davos Alzheimer’s Collaborative (DAC) announced that it will collaborate with health systems in Germany, the U.K., Japan, the U.S., and the Netherlands to leverage blood biomarkers and confirmatory diagnostic testing to for early identification of Alzheimer’s disease.

Quelle

Anderson, C. & Staff, I. (2024, 14. Juni). Global Research Program Launched to Deploy Blood Biomarker Testing of Alzheimer’s Disease. Inside Precision Medicine. https://www.insideprecisionmedicine.com/topics/molecular-dx/global-research-program-launched-to-deploy-blood-biomarker-testing-of-alzheimers-disease/?MailingID=%DEPLOYMENTID%&utm_medium=newsletter&utm_source=Inside+Precision+Medicine+Today&utm_content=01&utm_campaign=Inside+Precision+Medicine+Today_20240614&utm_id=1132813944

12.6.2024

High-Risk Parkinson’s Variant Discovered with Whole Genome and Exome Sequencing

High-Risk Parkinson’s Variant Discovered with Whole Genome and Exome Sequencing

"Familial cases" make up about 10-15% of Parkinson's disease patients; this label is traditionally reserved for those who are known to have at least one first-degree relative with the disease. These familial Parkinson's disease genes were discovered using various family-based study designs. However, traditional family-based research methods often fail to detect causal variants because of genetic diversity within families, low penetrance, and small sample sizes within families.

Quelle

Hop, P.J., Lai, D., Keagle, P.J. et al. Systematic rare variant analyses identify RAB32 as a susceptibility gene for familial Parkinson’s disease. Nat Genet (2024). https://doi.org/10.1038/s41588-024-01787-7

12.6.2024

Anti-Aging Gene Found by Comparing Insect and Human DNA

Anti-Aging Gene Found by Comparing Insect and Human DNA

A group of Chinese researchers have functionally validated the non-mitochondria-targeted nuclear gene, CG11837, which is conserved across animals, as having an effect on rate of aging. They also found a human gene, gene DIMT1, which is a 93 percent match with it.

Quelle

Tao, M., Chen, J., Cui, C. et al. Identification of a longevity gene through evolutionary rate covariation of insect mito-nuclear genomes. Nat Aging (2024). https://doi.org/10.1038/s43587-024-00641-z

12.6.2024

Ingestibles Offer Window into Gut Health

Ingestibles Offer Window into Gut Health

Two ingestible devices offer the opportunity to examine the condition of the gut without resorting to invasive hospital tests and could help personalize any treatments necessary.

Quelle

https://doi.org/10.1016/j.xcrp.2024.101990

10.6.2024

Lifespan in Mice Shortens with Increase in Nutrient Signaling to mTOR

Lifespan in Mice Shortens with Increase in Nutrient Signaling to mTOR

As the aging population increases, the race to unpack the molecular understanding of aging heats up. The rapamycin (mTOR) complex 1 (mTORC1) is known to be a key component of multiple functions of the body, including metabolism. Now, a new paper finds that when mTOR activity is just slightly increased in mice, the lifetime of animals can be shortened by up to 20%.

Quelle

Ortega-Molina, A., Lebrero-Fernández, C., Sanz, A. et al. A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation and shortened lifespan. Nat Aging (2024). https://doi.org/10.1038/s43587-024-00635-x

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SCIENCE.

EXPLAINED

Aging

Telomeres shorten over the course of a lifetime. The normal aging process is thought to be affected by telomere shortening and thus associated with the onset of disease and increased mortality in old age.

Length

Telomeres are protective caps at the ends of chromosomes that shorten each time a cell divides. When they become so short that the genes they protect could be damaged, cells stop dividing and renewing themselves. As a result, the cells are no longer able to perform their functions. This is thought to be one of the mechanisms of aging.

Function

Telomeres are protective caps at the ends of chromosomes that shorten each time a cell divides. When they become so short that the genes they protect could be damaged, cells stop dividing and renewing themselves. As a result, the cells become less able to perform their functions. This is thought to be one of the mechanisms of aging.

Through prevention and proactive measures. Eating habits: high consumption of meat (especially red meat), a generally fatty diet and obesity cause the chromosome caps to wear down, as does excessive alcohol consumption. Consumption of vegetable products protects the cells.
Physical activity: Interval and endurance training can lengthen telomeres

Protetion

science.
Explained

What are telomeres?

Are these tiny segments of DNA the key to aging?

3D-Render von einem Telomer
George Church, amerikanischer Genetiker
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Science.
Quote

The goal of a genome analysis is not to find out what you will die of, but rather to learn how to prevent diseases from occurring.

George Church

American geneticist, molecular engineer, chemist, and "founder of genomics"

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