Science
ABOUT science
The biology of aging is still largely a mystery. Researchers are working hard to unravel the molecular and cellular causes of aging and to find ways to prevent age-related diseases. These discoveries, and the science that may help people stay healthy as they age, are reported here.
SCIENCE.
NEWS
8.6.2025
Plasma exchange in humans lowers biological age by over two years
News
June 9, 2025
News
June 9, 2025
Plasma exchange in humans lowers biological age by over two years
In a randomized, placebo-controlled clinical trial, therapeutic plasma exchange combined with intravenous immunoglobulin reduced biological age by 2.6 years on average, as measured using multi-omics biomarkers.
Quelle
Fuentealba, M., Kiprov, D., Schneider, K., Mu, W.-C., Kumaar, P.A., Kasler, H., Burton, J.B., Watson, M., Halaweh, H., King, C.D., Yueksel, Z.S., Roska-Pamaong, C., Schilling, B., Verdin, E. and Furman, D. (2025), Multi-oman, D. Mics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Randomized Placebo-Controlled Therapeutic Plasma Exchange. Aging Cell e70103. https://doi.org/10.1111/acel.70103
30.5.2025
Neuroprotective mechanisms of exercise and the importance of fitness for healthy brain aging
News
May 30, 2025
News
May 30, 2025
Neuroprotective mechanisms of exercise and the importance of fitness for healthy brain aging
Exercise has a positive effect on brain health. Exciting new research shows that even brief physical activities can have a big impact on health.
Quelle
Neuroprotective mechanisms of exercise and the importance of fitness for healthy brain aging Tari, Atefe R et al. The Lancet, Volume 405, Issue 10484, 1093 - 1118
19.5.2025
Blood test predicts dementia up to 10 years in advance, study finds
News
May 19, 2025
News
May 19, 2025
Blood test predicts dementia up to 10 years in advance, study finds
A new study examined the potential of biomarkers tau217 and Neurofilament Light (NfL) to predict the onset of dementia up to ten years before clinical diagnosis in cognitively healthy older adults.
Quelle
“Blood-based biomarkers of Alzheimer's disease and incident dementia in the community” by Giulia Grande, Martina Valletta, Debora Rizzuto, Xin Xia, Chengxuan Qiu, Nicola Orsini, Matilda Dale, Sarah Andersson, Claudia Fredolini, Bengt Winblad, Erika J. Laukka, Laura Fratiglioni and Davide L. Vetrano, March 26, 2025, Nature Medicine.
24.4.2025
17 lifestyle factors that can be changed to protect the brain from aging and dementia
News
April 24, 2025
News
April 24, 2025
17 lifestyle factors that can be changed to protect the brain from aging and dementia
Age-related brain diseases such as stroke, dementia, and depression can significantly impair the quality of life of older people. However, many of these diseases are preventable. A comprehensive, systematic study by researchers at Mass General Brigham has identified 17 modifiable risk factors that apply to all three disorders.
Quelle
Modifiable risk factors for stroke, dementia and late-life depression: a systematic review and Daly-weighted risk factors for a composite outcome” by Jasper Senff, Reinier Willem Pieter Tack, Akashleena Mallick, Leidys Gutierrez-Martinez, Jonathan Duskin, Tamara N Kimball, Benjamin Y Q Tan, Zeina N Chemali, Amy Newhouse, Christina Kourkoulis, Cyprien Rivier, Guido J Falcone, Kevin N Sheth, Ronald M Lazar, Sarah Ibrahim, Aleksandra Pikula, Rudolph E Tanzi, Gregory L Fricchione, Hen's Bart Brouwers, Gabriel J E Rinkel, Nirupama Yechoor, Jonathan Rosand, Christopher D Anderson and Sanjula D Singh, April 3, 2025, Journal of Neurology, Neurosurgery & Psychiatry. DOI: 10.1136/jnnp-2024-334925
21.4.2025
Effect on autophagy and apoptosis after 7 days of cold water acclimatisation
News
April 21, 2025
News
April 21, 2025
Effect on autophagy and apoptosis after 7 days of cold water acclimatisation
New research from the University of Ottawa shows that repeated immersion in cold water helps the body better manage cellular stress. After just one week of daily exposure to cold water, participants showed improved autophagy — a cellular “recycling” system — and fewer signs of damage. This adjustment could provide protection against illness and aging, suggesting that cold acclimatization could be more than just a wellness trend.
Quelle
“The Effect of 7-Day Cold Water Acclimation on Autophagic and Apoptotic Responses in Young Males,” by Kelli E. King, James J. McCormick and Glen P. Kenny, November 27, 2024, Advanced Biology. DOI: 10.1002/adbi.202400111
SCIENCE.
EXPLAINED
Aging
Alterung
Telomeres shorten over the course of a lifetime. The normal aging process is thought to be affected by telomere shortening and thus associated with the onset of disease and increased mortality in old age.
Length
Länge
Telomeres are protective caps at the ends of chromosomes that shorten each time a cell divides. When they become so short that the genes they protect could be damaged, cells stop dividing and renewing themselves. As a result, the cells are no longer able to perform their functions. This is thought to be one of the mechanisms of aging.
Function
Funktion
Telomeres are protective caps at the ends of chromosomes that shorten each time a cell divides. When they become so short that the genes they protect could be damaged, cells stop dividing and renewing themselves. As a result, the cells become less able to perform their functions. This is thought to be one of the mechanisms of aging.
Schutz
Through prevention and proactive measures. Eating habits: high consumption of meat (especially red meat), a generally fatty diet and obesity cause the chromosome caps to wear down, as does excessive alcohol consumption. Consumption of vegetable products protects the cells.
Physical activity: Interval and endurance training can lengthen telomeres
Protetion
Science.
Quote
The goal of a genome analysis is not to find out what you will die of, but rather to learn how to prevent diseases from occurring.
George Church
American geneticist, molecular engineer, chemist, and "founder of genomics"
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