Live Longer, Better

Sirtuin

Enzymes that control longevity: They are found in organisms ranging from yeast to humans and require NAD to function. They remove acetyl and acyl groups from proteins to instruct them to protect cells from adversity, disease, and death. When fasting or exercising, sirtuin and NAD levels rise, which could explain why these activities are healthy. The SIRT genes (Sir2 homologues 1 to 7), which are named after the SIR2 gene in yeast, play a key role in protecting mammals against disease and decay.