Quercesome — a vital substance with increased bioavailability
The molecular complex has 20 times the bioavailability of other quercetin powders
Aaron Blanco Tejedor
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Quercetin is a naturally occurring flavonoid that is found in many plant foods such as onions, apples, grapes, capers, and green tea. Because of the multitude of positive properties attributed to the molecule, the vital substance is even referred to as the “king of flavonoids.”
Health benefits
Research suggests that the flavonoid has many benefits through its anti-inflammatory and antioxidant effects, ranging from supporting the immune system to reducing the risk of disease.
Antioxidant effects
As part of normal metabolism, the human body produces compounds called free radicals. Free radicals damage healthy cells, trigger gene mutations, accelerate aging and increase the risk of various diseases, including heart disease and diabetes.
With its powerful antioxidant effects, quercetin has been shown to help the body maintain a stable state, prevent premature aging and reduce the risk of chronic diseases. A majority of the studies have been carried out on cells or animals, but the researchers suspect that the effect can also be transferred to humans.
Antimicrobial effects
Several studies have found that quercetin has a wide range of antibacterial properties. Quercetin has been shown to protect against Salmonella enteritidis (Salmonella), Staphylococcus aureus (Staphylococcus) and Escherichia coli (E. coli), in part by destroying bacterial cell walls and altering cell function.
Quercetin has also been shown to inhibit the growth of drug-resistant microorganisms. This means quercetin can help fight bacterial strains that don't respond to treatment. Quercetin is particularly effective against bacteria that infect the skin, digestive system, respiratory and urinary tract. It has also been shown to fight some viruses and fungi.
May help with autoimmune diseases
Autoimmune diseases occur when the immune system mistakenly attacks the body's healthy cells. These conditions include rheumatoid arthritis (RA), inflammatory bowel disease, multiple sclerosis, and lupus.
Because of its protective, anti-inflammatory, and antioxidant properties, quercetin may help prevent or treat autoimmune diseases.
Heart health
Quercetin protects heart health in several ways.
1. Quercetin has been shown to lower both systolic (the top number) and diastolic (the bottom number) blood pressure and reduces pressure on the arteries. The latter is an important aspect because over time, high blood pressure can damage the arteries and lead to heart disease.
2. Quercetin has been shown to lower total cholesterol levels and triglycerides — a type of fat that in large amounts can increase the risk of heart disease.
3. Quercetin can counteract the oxidation process, which alters “bad” LDL cholesterol so that it hardens the arteries.
4. Quercetin may also help regenerate blood vessels to improve blood flow, which supports healthy heart function.
Cancer prevention
Based on cell and animal studies, it is assumed that quercetin has a protective effect against certain types of cancer and can help reduce the risk of cell degeneration.
Strengthening the immune system
Through synergistic effects, quercetin is also certified to have an immune-boosting effect, which can help prevent infections and diseases.
However, the problem with many secondary plant substances — including quercetin — is their bioavailability. Regardless of whether the molecule is absorbed naturally or in powder form — only a smaller portion of it is actually converted into the active form in the body. The bioavailability of quercetin depends on the degree of processing at the source, the method of administration and numerous other individual metabolic processes. In general, it is assumed that the bioavailability of quercetin from natural sources such as fruits and vegetables is relatively low because it is difficult to digest in the corresponding composition.
Moleqlar's specially formulated quercetin-C complex - Quercesome
Quercesome is a sophisticated combination of quercetin phospholipid and natural vitamin C made from the finest acerola fruit powder. High-purity quercetin is surrounded by a special phospholipid layer. Phospholipids are a type of fat molecule that are commonly found in cell membranes and can improve the bioavailability of molecules. The result of the special Quercesome formulation is excellent: a 20-fold increase in bioavailability compared to conventional quercetin powder (see chart).
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A study carried out in 2018 says: “A more soluble lecithin-based formulation of quercetin was recently developed. It was found that when the novel formulation is administered orally to volunteers, very high plasma levels of quercetin can be achieved — up to 20 times more than with the usual administration of quercetin — and that it has no significant side effects. These results suggest that the novel formulation allows quercetin to be administered orally in a safe and bioavailable manner, thus facilitating the effective use of this natural agent to treat various human diseases. ”
A study published recently (2022) confirms that there is plenty of evidence for the potentially beneficial biological benefits of quercetin in combination with phospholipids. First, the complex increases plasmatic levels of quercetin and improves quercetin bioabsorption by up to 20-fold after oral administration of a single dose compared to unformulated quercetin in a pharmacokinetic study in humans. In addition, the formulation has a remarkably favorable safety profile. The interaction between quercetin paired with phospholipids and the human microbiome was also elucidated. This latest evidence confirmed that quercetin formulation is more stable than unformulated quercetin after interaction with the gut microbiota. In fact, the combination can slow down the microbial breakdown of quercetin in the intestine so that more time is available and the individual molecule can be better dispersed to be absorbed, improving one of the possible reasons for quercetin's poor oral bioavailability, as reported by Riva and colleagues.
Moleqlar's Quercesome and other Longevity products are available at www.moleqlar.de.
References
- Yang D, Wang T, Long M, Li P. Quercetin: its main pharmacological activity and potential application in clinical medicine. Oxid Med Cell Longev. 2020; 2020:8825387. doi:10.1155/2020/8825387
- Lee JS, Cha TJ, Lee KH, Yim JE. Onion peel extract reduces the percentage of body fat in overweight and obese subjects: a 12-week, randomized, double-blind, placebo-controlled study. Nutr Res Pract. 2016; 10 (2) :175—181. doi:10.4162/nrp.2016.10.2.175
- Heinz SA, Henson DA, Austin MD, Jin F, Nieman DC. Quercetin supplementation and upper respiratory tract infection: A randomized community clinical trial. Pharmacol Res. 2010; 62 (3) :237—242. doi:10.1016/j.phrs.2010.05.001
- Nishihira J, Nishimura M, Kurimoto M, et al. The effect of 24-week continuous intake of quercetin-rich onion on age-related cognitive decline in healthy elderly people: a randomized, double-blind, placebo-controlled, parallel-group comparative clinical trial. J Clin Biochem Nutr. 2021; 69 (2) :203—215. doi:10.3164/jcbn.21-17
- Yang D, Wang T, Long M, Li P. Quercetin: its main pharmacological activity and potential application in clinical medicine. Oxid Med Cell Longev. 2020; 2020:8825387. doi:10.1155/2020/8825387
- Riva, A., Ronchi, M., Petrangolini, G., Bosisio, S. & Allegrini, P. (2018). Improved Oral Absorption of Quercetin from Quercetin Phytosome®, a New Delivery System Based on Food Grade Lecithin. European Journal of Drug Metabolism and Pharmacokinetics, 44(2), 169—177. https://doi.org/10.1007/s13318-018-0517-3
- Rondanelli, M., Perna, S., Gasparri, C., Petrangolini, G., Allegrini, P., Cavioni, A., Faliva, M.A., Mansueto, F., Patelli, Z., Peroni, G., Tartara, A. & Riva, A. (2022). Promising Effects of 3-Month Period of Quercetin Phytosome® Supplementation in the Prevention of Symptomatic COVID-19 Disease in Healthcare Workers: A Pilot Study. Life, 12(1), 66. https://doi.org/10.3390/life12010066
Publiziert
17.3.2024
Kategorie
Lifestyle
Quercetin is a naturally occurring flavonoid that is found in many plant foods such as onions, apples, grapes, capers, and green tea. Because of the multitude of positive properties attributed to the molecule, the vital substance is even referred to as the “king of flavonoids.”
Health benefits
Research suggests that the flavonoid has many benefits through its anti-inflammatory and antioxidant effects, ranging from supporting the immune system to reducing the risk of disease.
Antioxidant effects
As part of normal metabolism, the human body produces compounds called free radicals. Free radicals damage healthy cells, trigger gene mutations, accelerate aging and increase the risk of various diseases, including heart disease and diabetes.
With its powerful antioxidant effects, quercetin has been shown to help the body maintain a stable state, prevent premature aging and reduce the risk of chronic diseases. A majority of the studies have been carried out on cells or animals, but the researchers suspect that the effect can also be transferred to humans.
Antimicrobial effects
Several studies have found that quercetin has a wide range of antibacterial properties. Quercetin has been shown to protect against Salmonella enteritidis (Salmonella), Staphylococcus aureus (Staphylococcus) and Escherichia coli (E. coli), in part by destroying bacterial cell walls and altering cell function.
Quercetin has also been shown to inhibit the growth of drug-resistant microorganisms. This means quercetin can help fight bacterial strains that don't respond to treatment. Quercetin is particularly effective against bacteria that infect the skin, digestive system, respiratory and urinary tract. It has also been shown to fight some viruses and fungi.
May help with autoimmune diseases
Autoimmune diseases occur when the immune system mistakenly attacks the body's healthy cells. These conditions include rheumatoid arthritis (RA), inflammatory bowel disease, multiple sclerosis, and lupus.
Because of its protective, anti-inflammatory, and antioxidant properties, quercetin may help prevent or treat autoimmune diseases.
Heart health
Quercetin protects heart health in several ways.
1. Quercetin has been shown to lower both systolic (the top number) and diastolic (the bottom number) blood pressure and reduces pressure on the arteries. The latter is an important aspect because over time, high blood pressure can damage the arteries and lead to heart disease.
2. Quercetin has been shown to lower total cholesterol levels and triglycerides — a type of fat that in large amounts can increase the risk of heart disease.
3. Quercetin can counteract the oxidation process, which alters “bad” LDL cholesterol so that it hardens the arteries.
4. Quercetin may also help regenerate blood vessels to improve blood flow, which supports healthy heart function.
Cancer prevention
Based on cell and animal studies, it is assumed that quercetin has a protective effect against certain types of cancer and can help reduce the risk of cell degeneration.
Strengthening the immune system
Through synergistic effects, quercetin is also certified to have an immune-boosting effect, which can help prevent infections and diseases.
However, the problem with many secondary plant substances — including quercetin — is their bioavailability. Regardless of whether the molecule is absorbed naturally or in powder form — only a smaller portion of it is actually converted into the active form in the body. The bioavailability of quercetin depends on the degree of processing at the source, the method of administration and numerous other individual metabolic processes. In general, it is assumed that the bioavailability of quercetin from natural sources such as fruits and vegetables is relatively low because it is difficult to digest in the corresponding composition.
Moleqlar's specially formulated quercetin-C complex - Quercesome
Quercesome is a sophisticated combination of quercetin phospholipid and natural vitamin C made from the finest acerola fruit powder. High-purity quercetin is surrounded by a special phospholipid layer. Phospholipids are a type of fat molecule that are commonly found in cell membranes and can improve the bioavailability of molecules. The result of the special Quercesome formulation is excellent: a 20-fold increase in bioavailability compared to conventional quercetin powder (see chart).
A study carried out in 2018 says: “A more soluble lecithin-based formulation of quercetin was recently developed. It was found that when the novel formulation is administered orally to volunteers, very high plasma levels of quercetin can be achieved — up to 20 times more than with the usual administration of quercetin — and that it has no significant side effects. These results suggest that the novel formulation allows quercetin to be administered orally in a safe and bioavailable manner, thus facilitating the effective use of this natural agent to treat various human diseases. ”
A study published recently (2022) confirms that there is plenty of evidence for the potentially beneficial biological benefits of quercetin in combination with phospholipids. First, the complex increases plasmatic levels of quercetin and improves quercetin bioabsorption by up to 20-fold after oral administration of a single dose compared to unformulated quercetin in a pharmacokinetic study in humans. In addition, the formulation has a remarkably favorable safety profile. The interaction between quercetin paired with phospholipids and the human microbiome was also elucidated. This latest evidence confirmed that quercetin formulation is more stable than unformulated quercetin after interaction with the gut microbiota. In fact, the combination can slow down the microbial breakdown of quercetin in the intestine so that more time is available and the individual molecule can be better dispersed to be absorbed, improving one of the possible reasons for quercetin's poor oral bioavailability, as reported by Riva and colleagues.
Moleqlar's Quercesome and other Longevity products are available at www.moleqlar.de.
Referenzen
- Yang D, Wang T, Long M, Li P. Quercetin: its main pharmacological activity and potential application in clinical medicine. Oxid Med Cell Longev. 2020; 2020:8825387. doi:10.1155/2020/8825387
- Lee JS, Cha TJ, Lee KH, Yim JE. Onion peel extract reduces the percentage of body fat in overweight and obese subjects: a 12-week, randomized, double-blind, placebo-controlled study. Nutr Res Pract. 2016; 10 (2) :175—181. doi:10.4162/nrp.2016.10.2.175
- Heinz SA, Henson DA, Austin MD, Jin F, Nieman DC. Quercetin supplementation and upper respiratory tract infection: A randomized community clinical trial. Pharmacol Res. 2010; 62 (3) :237—242. doi:10.1016/j.phrs.2010.05.001
- Nishihira J, Nishimura M, Kurimoto M, et al. The effect of 24-week continuous intake of quercetin-rich onion on age-related cognitive decline in healthy elderly people: a randomized, double-blind, placebo-controlled, parallel-group comparative clinical trial. J Clin Biochem Nutr. 2021; 69 (2) :203—215. doi:10.3164/jcbn.21-17
- Yang D, Wang T, Long M, Li P. Quercetin: its main pharmacological activity and potential application in clinical medicine. Oxid Med Cell Longev. 2020; 2020:8825387. doi:10.1155/2020/8825387
- Riva, A., Ronchi, M., Petrangolini, G., Bosisio, S. & Allegrini, P. (2018). Improved Oral Absorption of Quercetin from Quercetin Phytosome®, a New Delivery System Based on Food Grade Lecithin. European Journal of Drug Metabolism and Pharmacokinetics, 44(2), 169—177. https://doi.org/10.1007/s13318-018-0517-3
- Rondanelli, M., Perna, S., Gasparri, C., Petrangolini, G., Allegrini, P., Cavioni, A., Faliva, M.A., Mansueto, F., Patelli, Z., Peroni, G., Tartara, A. & Riva, A. (2022). Promising Effects of 3-Month Period of Quercetin Phytosome® Supplementation in the Prevention of Symptomatic COVID-19 Disease in Healthcare Workers: A Pilot Study. Life, 12(1), 66. https://doi.org/10.3390/life12010066
Publiziert
17.3.2024
Kategorie
Lifestyle
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