NAD+: Function, Benefits, and Effective Ways to Support Your Levels
Why NAD+ matters for energy, healthy aging, and cell vitality – including latest research and tips for boosting your levels
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The molecule NAD+ (nicotinamide adenine dinucleotide) plays a central role in our body. It is involved in over 500 metabolic processes — including energy production, DNA repair, metabolism regulation and the protection of mitochondria, the “power plants” of our cells.
However, as we age, NAD+ levels fall continuously. Studies show that it decreases significantly from the age of 40 — in old age, the values may even fall to less than 50% of the initial level. This decline is associated with fatigue, reduced ability to regenerate and an accelerated aging process.
Why NAD+ is so important for healthy aging
A stable NAD+ level makes a decisive contribution to our cells being able to work optimally. The focus is on three main areas:
- Energy production in the cells
NAD+ is essential for converting nutrients into energy (ATP). A deficiency can result in chronic fatigue and loss of performance.
- DNA and cell repair
NAD+-dependent enzymes such as Sirtuine and PARPs repair damaged DNA strands. Low NAD+ levels cause cell damage to build up over time.
- Metabolism & inflammatory processes
NAD+ influences signaling pathways that occur in insulin resistance, inflammatory processes and cellular aging play a role. Stable NAD+ levels can reduce inflammation and support healthy aging.
NAD+, NMN, and NR — what's the difference?
In discussions about healthy aging, energy production and longevity, similar but not identical terms come up again and again: NAD+, NMN and NR. They all belong to the same metabolic path and are closely interrelated — yet they have different functions. To avoid misunderstandings, it's worth taking a closer look at how they work together:
- NAD+ — the central player
NAD+ (nicotinamide adenine dinucleotide) is the actual coenzyme that acts directly in the cells. It is essential for energy production, the DNA repair and the protection of mitochondria. Without NAD+, cells cannot function optimally.
- NMN — the direct precursor
NMN (nicotinamide mononucleotide) is a molecule that the body uses to produce NAD+. It is converted directly into NAD+ in just a few steps — which is why it is often referred to as the “building block” for NAD+. Dietary supplements with NMN provide the body with this direct precursor.
- NR — the indirect precursor
NO (nicotinamide riboside) belongs to the vitamin B3 family. In the body, NR is first converted into NMN and then into NAD+. NR is well researched and is often used in supplements because it is well tolerated.
Studies show that both NR and NMN increase NAD+ levels in humans are able to increase sustainably, which in turn supports processes such as energy production and cell repair.
Current research on NAD+ precursors
Numerous studies have shown the effects of NAD+ precursors such as NMN and NR investigated. An overview of the most important results:
- Safety: Several reviews show that NR and NMN are well tolerated and reliably increase NAD+ levels in the blood (Yaku et al., 2023).
- Potential for diseases: Preclinical data suggest benefits for age-related diseases such as cardiovascular and metabolic disorders, even though larger human studies are still missing (Reiten et al., 2021).
- Criticism: Initial human studies show only moderate effects; long-term effects must be confirmed in larger studies (Damgaard et al., 2023).
- Highlights: In the short term, for example, an increase in muscle strength (Yoshino, 2011), improved metabolic markers (Elhassan, 2019) and heart protection effects (Zhang, 2020) could be observed.
NR and NMN increase NAD+ levels reliably and are considered safe. Research shows promising approaches for better cell health and anti-aging, but lasting, clinically relevant effects have yet to be clearly proven.
Dietary supplement as targeted anti-aging support
In addition to a healthy lifestyle, we can high-quality supplements with NAD+ precursors provide the body with additional supplies. In particular, NR and NMN are used here, which have proven effective in studies to increase NAD+ levels in humans — without relevant side effects.
Some preparations, such as the NAD+ booster from Purovitalis, combine NR with additional ingredients such as vitamin B3 and antioxidants. The aim of this combination is not only to increase NAD+ levels, but also to support cell protection and mitochondrial function.
NAD+ as a basis for cell health
NAD+ is much more than just a metabolic molecule — it is a central component of vitality, energy production and healthy aging. An active lifestyle, adequate sleep and a nutrient-rich diet form the basis for stable NAD+ levels. If you also want targeted support, you can rely on high-quality supplements.
The NAD+ booster from Purovitalis combines NR with vitamin B3 (NAM), PQQ (Pyrroloquinoline quinone, a vitamin-like substance that helps support mitochondria) and antioxidants from blueberries. This synergy should not only stimulate NAD+ metabolism, but also comprehensively promote cell health.
The product is used in Europe under strict conditions Made with quality standards, is vegan, gluten-free and has been independently tested. It is aimed at people who cell energy, regeneration and healthy aging want to provide long-term support.
Our experience
For these reasons, we tried the NAD+ Booster and were able to see that after a few weeks slight improvements in energy and mental clarity noticeable, especially on days with a lot of stress. The effect was not sudden or strongly felt, but was more apparent as continuous sense of balance and focus. We also appreciated that the product is good for a longer-term use suitable — constant support for cell health and vitality over weeks.
For more infomation about the selected ingredients and the clinical research behind it visit https://purovitalis.com.
Additional FAQs
What effect does NAD+ have in the body?
NAD+ supports over 500 metabolic processes, including energy production (ATP), DNA repair, and mitochondrial function. A stable NAD+ level contributes to more vitality, regeneration and healthy cell function.
How do I notice a low NAD+ level?
Typical signs include fatigue, reduced resilience, slower regeneration after stress or sport, and vulnerability to inflammation. These symptoms are unspecific but may indicate declining cell energy.
Which foods can support NAD+ levels?
Foods rich in vitamin B3, such as fish, poultry, mushrooms, nuts and whole grains, are particularly helpful. Fasting phases and a balanced diet also have a positive effect on NAD+ metabolism.
When is it worth taking an NAD+ booster?
Anyone who suffers from lack of energy, signs of aging or increased stress can benefit from NAD+ precursors such as NR or NMN. Especially after 40, the body's own NAD+ level drops sharply, so supplements can be a useful addition.
Is NAD+ the same as an anti-aging agent?
NAD+ is not a classic anti-aging agent, but an endogenous coenzyme that supports central processes such as energy production and DNA repair. However, aging processes can be positively influenced by stable levels.
Are NAD+ precursor supplements safe?
Recent studies show that NR and NMN are generally well tolerated. To date, no serious side effects have been identified. However, the intake should ideally be coordinated with a specialist (e.g. doctor or nutritionist).
We may receive compensation for brokered purchases. This does not affect our independent opinion.
References
Publiziert
12.9.2025
Kategorie
Lifestyle
Experte
Scientific Terms
Antioxidants
Free radical scavengers. These are molecules that intercept or neutralise free radicals by giving their electrons something to bind to. Examples of antioxidants include glutathione (GSH), ubiquinone (CoQ10), polyphenols (found in tea) and vitamin E.
DNA
Abbreviation for deoxyribonucleic acid, the molecule that encodes the information that a cell needs to function or a virus needs to replicate. Forms a double helix that resembles a twisted ladder, similar to a zipper. The bases, abbreviated as A, C, T, and G, are on either side of the ladder or strand that run in opposite directions. The bases exert an attraction on each other so that A sticks to T and C to G. The sequence of these letters is known as the genetic code.
Free radical
A free radical is a molecule or atom that has at least one unpaired electron. These electrons make the radical very reactive - it easily 'steals' electrons from other molecules, which can lead to cell damage. Free radicals are produced by metabolic processes, UV radiation or environmental toxins, for example. They play a role in ageing and disease, but are also used specifically by the body, for example to fight off pathogens.
Inflammaging
Inflammatory aging (the English term inflam-aging or inflammaging is also widely used in German-speaking countries) refers to the increased release of pro-inflammatory cytokines and associated chronic diseases in older people.
Cellular Senescence
The process that occurs when normal cells stop dividing and start releasing inflammatory molecules, sometimes caused by telomere shortening, DNA damage, or epigenomic noise. Despite their apparent “zombie” state, senescent cells remain alive and damage neighboring cells with their inflammatory secretions.
Sirtuin
Enzymes that control longevity: They are found in organisms ranging from yeast to humans and require NAD to function. They remove acetyl and acyl groups from proteins to instruct them to protect cells from adversity, disease, and death. When fasting or exercising, sirtuin and NAD levels rise, which could explain why these activities are healthy. The SIRT genes (Sir2 homologues 1 to 7), which are named after the SIR2 gene in yeast, play a key role in protecting mammals against disease and decay.
The molecule NAD+ (nicotinamide adenine dinucleotide) plays a central role in our body. It is involved in over 500 metabolic processes — including energy production, DNA repair, metabolism regulation and the protection of mitochondria, the “power plants” of our cells.
However, as we age, NAD+ levels fall continuously. Studies show that it decreases significantly from the age of 40 — in old age, the values may even fall to less than 50% of the initial level. This decline is associated with fatigue, reduced ability to regenerate and an accelerated aging process.
Why NAD+ is so important for healthy aging
A stable NAD+ level makes a decisive contribution to our cells being able to work optimally. The focus is on three main areas:
- Energy production in the cells
NAD+ is essential for converting nutrients into energy (ATP). A deficiency can result in chronic fatigue and loss of performance.
- DNA and cell repair
NAD+-dependent enzymes such as Sirtuine and PARPs repair damaged DNA strands. Low NAD+ levels cause cell damage to build up over time.
- Metabolism & inflammatory processes
NAD+ influences signaling pathways that occur in insulin resistance, inflammatory processes and cellular aging play a role. Stable NAD+ levels can reduce inflammation and support healthy aging.
NAD+, NMN, and NR — what's the difference?
In discussions about healthy aging, energy production and longevity, similar but not identical terms come up again and again: NAD+, NMN and NR. They all belong to the same metabolic path and are closely interrelated — yet they have different functions. To avoid misunderstandings, it's worth taking a closer look at how they work together:
- NAD+ — the central player
NAD+ (nicotinamide adenine dinucleotide) is the actual coenzyme that acts directly in the cells. It is essential for energy production, the DNA repair and the protection of mitochondria. Without NAD+, cells cannot function optimally.
- NMN — the direct precursor
NMN (nicotinamide mononucleotide) is a molecule that the body uses to produce NAD+. It is converted directly into NAD+ in just a few steps — which is why it is often referred to as the “building block” for NAD+. Dietary supplements with NMN provide the body with this direct precursor.
- NR — the indirect precursor
NO (nicotinamide riboside) belongs to the vitamin B3 family. In the body, NR is first converted into NMN and then into NAD+. NR is well researched and is often used in supplements because it is well tolerated.
Studies show that both NR and NMN increase NAD+ levels in humans are able to increase sustainably, which in turn supports processes such as energy production and cell repair.
Current research on NAD+ precursors
Numerous studies have shown the effects of NAD+ precursors such as NMN and NR investigated. An overview of the most important results:
- Safety: Several reviews show that NR and NMN are well tolerated and reliably increase NAD+ levels in the blood (Yaku et al., 2023).
- Potential for diseases: Preclinical data suggest benefits for age-related diseases such as cardiovascular and metabolic disorders, even though larger human studies are still missing (Reiten et al., 2021).
- Criticism: Initial human studies show only moderate effects; long-term effects must be confirmed in larger studies (Damgaard et al., 2023).
- Highlights: In the short term, for example, an increase in muscle strength (Yoshino, 2011), improved metabolic markers (Elhassan, 2019) and heart protection effects (Zhang, 2020) could be observed.
NR and NMN increase NAD+ levels reliably and are considered safe. Research shows promising approaches for better cell health and anti-aging, but lasting, clinically relevant effects have yet to be clearly proven.
Dietary supplement as targeted anti-aging support
In addition to a healthy lifestyle, we can high-quality supplements with NAD+ precursors provide the body with additional supplies. In particular, NR and NMN are used here, which have proven effective in studies to increase NAD+ levels in humans — without relevant side effects.
Some preparations, such as the NAD+ booster from Purovitalis, combine NR with additional ingredients such as vitamin B3 and antioxidants. The aim of this combination is not only to increase NAD+ levels, but also to support cell protection and mitochondrial function.
NAD+ as a basis for cell health
NAD+ is much more than just a metabolic molecule — it is a central component of vitality, energy production and healthy aging. An active lifestyle, adequate sleep and a nutrient-rich diet form the basis for stable NAD+ levels. If you also want targeted support, you can rely on high-quality supplements.
The NAD+ booster from Purovitalis combines NR with vitamin B3 (NAM), PQQ (Pyrroloquinoline quinone, a vitamin-like substance that helps support mitochondria) and antioxidants from blueberries. This synergy should not only stimulate NAD+ metabolism, but also comprehensively promote cell health.
The product is used in Europe under strict conditions Made with quality standards, is vegan, gluten-free and has been independently tested. It is aimed at people who cell energy, regeneration and healthy aging want to provide long-term support.
Our experience
For these reasons, we tried the NAD+ Booster and were able to see that after a few weeks slight improvements in energy and mental clarity noticeable, especially on days with a lot of stress. The effect was not sudden or strongly felt, but was more apparent as continuous sense of balance and focus. We also appreciated that the product is good for a longer-term use suitable — constant support for cell health and vitality over weeks.
For more infomation about the selected ingredients and the clinical research behind it visit https://purovitalis.com.
Additional FAQs
What effect does NAD+ have in the body?
NAD+ supports over 500 metabolic processes, including energy production (ATP), DNA repair, and mitochondrial function. A stable NAD+ level contributes to more vitality, regeneration and healthy cell function.
How do I notice a low NAD+ level?
Typical signs include fatigue, reduced resilience, slower regeneration after stress or sport, and vulnerability to inflammation. These symptoms are unspecific but may indicate declining cell energy.
Which foods can support NAD+ levels?
Foods rich in vitamin B3, such as fish, poultry, mushrooms, nuts and whole grains, are particularly helpful. Fasting phases and a balanced diet also have a positive effect on NAD+ metabolism.
When is it worth taking an NAD+ booster?
Anyone who suffers from lack of energy, signs of aging or increased stress can benefit from NAD+ precursors such as NR or NMN. Especially after 40, the body's own NAD+ level drops sharply, so supplements can be a useful addition.
Is NAD+ the same as an anti-aging agent?
NAD+ is not a classic anti-aging agent, but an endogenous coenzyme that supports central processes such as energy production and DNA repair. However, aging processes can be positively influenced by stable levels.
Are NAD+ precursor supplements safe?
Recent studies show that NR and NMN are generally well tolerated. To date, no serious side effects have been identified. However, the intake should ideally be coordinated with a specialist (e.g. doctor or nutritionist).
We may receive compensation for brokered purchases. This does not affect our independent opinion.
Experte
Referenzen
Publiziert
12.9.2025
Kategorie
Lifestyle
Wissenschaftliche Begriffe
Antioxidants
Free radical scavengers. These are molecules that intercept or neutralise free radicals by giving their electrons something to bind to. Examples of antioxidants include glutathione (GSH), ubiquinone (CoQ10), polyphenols (found in tea) and vitamin E.
DNA
Abbreviation for deoxyribonucleic acid, the molecule that encodes the information that a cell needs to function or a virus needs to replicate. Forms a double helix that resembles a twisted ladder, similar to a zipper. The bases, abbreviated as A, C, T, and G, are on either side of the ladder or strand that run in opposite directions. The bases exert an attraction on each other so that A sticks to T and C to G. The sequence of these letters is known as the genetic code.
Free radical
A free radical is a molecule or atom that has at least one unpaired electron. These electrons make the radical very reactive - it easily 'steals' electrons from other molecules, which can lead to cell damage. Free radicals are produced by metabolic processes, UV radiation or environmental toxins, for example. They play a role in ageing and disease, but are also used specifically by the body, for example to fight off pathogens.
Inflammaging
Inflammatory aging (the English term inflam-aging or inflammaging is also widely used in German-speaking countries) refers to the increased release of pro-inflammatory cytokines and associated chronic diseases in older people.
Cellular Senescence
The process that occurs when normal cells stop dividing and start releasing inflammatory molecules, sometimes caused by telomere shortening, DNA damage, or epigenomic noise. Despite their apparent “zombie” state, senescent cells remain alive and damage neighboring cells with their inflammatory secretions.
Sirtuin
Enzymes that control longevity: They are found in organisms ranging from yeast to humans and require NAD to function. They remove acetyl and acyl groups from proteins to instruct them to protect cells from adversity, disease, and death. When fasting or exercising, sirtuin and NAD levels rise, which could explain why these activities are healthy. The SIRT genes (Sir2 homologues 1 to 7), which are named after the SIR2 gene in yeast, play a key role in protecting mammals against disease and decay.
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