New anti-aging aspects through spermidine supplementation
Spermidine increases autophagy activity and has been shown to extend lifespan.
Erdikocak @iStock
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One of the biggest benefits of spermidine is its ability to reduce the activity of autophagy by breaking down cell waste from old cells, which is then used to repair the cell. This process is associated with extended lifespan and improved cell health, as it reduces the risk of aging processes and diseases.
A great way to stimulate autophagy is fasting, but that's not for everyone. Thankfully, there's a natural compound that can stimulate autophagy without fasting, and that's spermidine.
What is spermidine?
On a molecular level, spermidine is a natural polyamine, i.e. a compound with more than two amino groups, and it is endogenous, meaning it is produced in the body up to the age of 30. It can be produced in tissue or by bacteria in the intestine and, together with several other polyamines, appears to be a universal prerequisite for growth, which have an effect on cell proliferation and cell differentiation.
Studies have also shown that spermidine can inhibit the development of cancer and slow down aging. It is currently being investigated in medical research to explore its potential therapeutic uses.
What does spermidine do?
Put simply, spermidine stimulates autophagy. The term “autophagy” comes from the Greek words “phagy” for “to eat” and “auto” for “self” and stands for a process that takes place in our body. When nutrients become scarce, cells can generate additional energy by recycling old or worn out, poorly functioning cell components. In addition to generating energy, this process renews the cell and makes it healthier.
Under normal conditions, autophagy in the body takes at least 24 hours fasting Set in motion. Should autophagy persist for a while, the fast would have to be continued for longer than 24 hours. Not only does this require a lot of discipline, fasting is unpleasant for most people. Spermidine, on the other hand, can stimulate autophagy without fasting for a long time or even by acting on the molecular signaling pathways that control aging.
While fasting causes the body to draw on its energy reserves to maintain the necessary processes, spermidine increases autophagy activity by stimulating the protein kinase mTORC1.
A study has shown that combining spermidine and fasting increases autophagy activity compared to fasting alone. These findings suggest that spermidine may help amplify the benefits of fasting by speeding up cell repair and detoxification.
But beyond that, spermidine has been shown to have several very specific effects.
Some studies suggest that it anti-inflammatory properties has and is involved in cell growth and proliferation as well as in programmed cell death, known as apoptosis, resulting in a reduced development of cancer can contribute. It has also shown that it can inhibit tumor growth and improve the survival of cancer patients. Spermidine also works by reducing lipid metabolism , which helps to regulate the life span.
Another benefit of spermidine is its ability to reduce the risk of cardiovascular diseases to reduce. Studies have shown that spermidine improves the effects of fasting on insulin sensitivity and helps reduce the risk of cardiovascular disease. It is thought that this is due to spermidine's ability to promote blood vessel formation and improve circulation.
Does taking spermidine actually extend life expectancy?
In a study published last year on mice, researchers wanted to find out how spermidine affects the organs that are usually most affected by the aging process. At the end of the study, they found that the mice treated with spermidine showed noticeable anti-aging effects, as opposed to mice of the same age that were not treated with spermidine. Thanks to spermidine treatment, the mice developed less kidney and liver damage in the experiment. The bald patches that typically occur in aging mice were also fewer in the mice treated with spermidine.
What impressed researchers the most was how spermidine helped to shorten the telomeres to decrease in heart tissue. Telomeres are the caps at the ends of chromosomes that protect DNA strands. In mice treated with spermidine, the telomeres were almost the same length as in younger mice. All of this research raises the question of whether taking spermidine actually extends people's life expectancy. Well, apparently it does.
Spermidine consumption
The good thing about spermidine is that it is found in plant foods, such as wheat germ, vegetable sprouts, mushrooms, peas, cauliflower, and broccoli. These foods all have a high spermidine content, but it is difficult to determine the exact spermidine content as the soil, cultivation and variety influence the polyamine content.
As the body's own production of spermidine in tissues or in our intestines decreases with increasing age, spermidine levels fall. Supplementing with spermidine supplements can be a way to consciously and specifically increase spermidine levels in the body.
The Austrian company Longevity Labs offers pure natural spermidine in the form of dietary supplements. They extract the active ingredient from GMO-free wheat germ from Central Europe and, according to Dave Asprey, it's the first permanent supplement he's found that meets his criteria for clean ingredients.
If you do not want to fast for health, time or personal reasons or do something good for your body even outside fasting periods, you can of course also implement the positive fasting effects of cell cleansing with a simple solution: with spermidineLIFE®. Together with zinc, it has a function in cell division, contributes to normal DNA and protein synthesis, and to protecting the cell from oxidative stress. spermidineLIFE® can increase cell repair and speed up cell cleansing without fasting.
References
- Fernández, L.F., Bárcena, C., Martínez-García, G.G., Tamargo-Gomez, I., Suárez, M.F., Pietrocola, F., Castoldi, F., Esteban, L., Sierra-Filardi, E., Boya, P., Lopez-Otín, C., Krömer, G. & Mariño, G. (2017). Autophagy couteracts weight gain, lipotoxicity and pancreatic β-cell death upon hypercaloric pro-diabetic regimens. Cell Death & Disease, 8(8), e2970—e2970. https://doi.org/10.1038/cddis.2017.373
- Levesque, S., Le Naour, J., Pietrocola, F., Paillet, J., Kremer, M., Castoldi, F., Baracco, E.E., Wang, Y., Vacchelli, E., Stoll, G., Jolly, A., De La Grange, P., Zitvogel, L., Krömer, G. & Pol, J.G. (2019). A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice. OncoImmunology, 8(11), e1657375. https://doi.org/10.1080/2162402x.2019.1657375
- Hofer, S.J., Davinelli, S., Bergmann, M., Scapagnini, G. & Madeo, F. (2021). Caloric Restriction Mimetics in Nutrition and Clinical Trials. Frontiers in Nutrition, 8. https://doi.org/10.3389/fnut.2021.717343
- Hofer, S.J., Carmona-Gutierrez, D., Müller, M.I. & Madeo, F. (2021). The ups and downs of caloric restriction and fasting: from molecular effects to clinical application. EMBO Molecular Medicine, 14(1). https://doi.org/10.15252/emmm.202114418
- Fan, J., Feng, Z. & Chen, N. (2020). Spermidine as a target for cancer therapy. Pharmacological Research, 159, 104943. https://doi.org/10.1016/j.phrs.2020.104943
- Singh, S., Kumar, R., Garg, G., Singh, A.K., Verma, A.K., Bissoyi, A. & Rizvi, S.I. (2020). Spermidine, a caloric restriction mimetic, provides neuroprotection against normal and d-galactose-induced oxidative stress and apoptosis through activation of autophagy in male rats during aging. Biogerontology, 22(1), 35—47. https://doi.org/10.1007/s10522-020-09900-z
- Soda, K. (2022). Overview of Polyamines as Nutrients for Human Healthy Long Life and Effect of Increased Polyamine Intake on DNA Methylation. Cells, 11(1) 164. https://doi.org/10.3390/cells11010164
- Schröder, S., Hofer, S.J., Zimmermann, A., Pechlaner, R., Dammbrück, C., Pendl, T., Marcello, G.M., Pogatschnigg, V., Bergmann, M., Gschiel, V., Ristic, S., Tadic, J., Iwata, K., Richter, G., Farzi, A., Üçal, M., Schäfer, U., Poglich, M.,. Madeo, F (2021). Dietary spermidine improves cognitive function. Cell Reports, 35(2), 108985. https://doi.org/10.1016/j.celrep.2021.108985
- Wirth, A., Wolf, B., Huang, C.K., Glage, S., Hofer, S.J., Bankstahl, M., Baer, C., Thum, T., Kahl, K.G., Sigrist, S.J., Madeo, F., Bankstahl, J.P. & Ponimaskin, E. (2021). Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length. GeroScience, 43(2), 673—690. https://doi.org/10.1007/s11357-020-00310-0
- Lumkwana, D., Peddie, C., Kriel, J., Michie, L.L., Heathcote, N., Collinson, L., Kinnear, C. & Loos, B. (2022). Investigating the Role of Spermidine in a Model System of Alzheimer's Disease Using Correlative Microscopy and Super-resolution Techniques. Frontiers in Cell and Developmental Biology, 10. https://doi.org/10.3389/fcell.2022.819571
Publiziert
17.3.2024
Kategorie
Lifestyle
One of the biggest benefits of spermidine is its ability to reduce the activity of autophagy by breaking down cell waste from old cells, which is then used to repair the cell. This process is associated with extended lifespan and improved cell health, as it reduces the risk of aging processes and diseases.
A great way to stimulate autophagy is fasting, but that's not for everyone. Thankfully, there's a natural compound that can stimulate autophagy without fasting, and that's spermidine.
What is spermidine?
On a molecular level, spermidine is a natural polyamine, i.e. a compound with more than two amino groups, and it is endogenous, meaning it is produced in the body up to the age of 30. It can be produced in tissue or by bacteria in the intestine and, together with several other polyamines, appears to be a universal prerequisite for growth, which have an effect on cell proliferation and cell differentiation.
Studies have also shown that spermidine can inhibit the development of cancer and slow down aging. It is currently being investigated in medical research to explore its potential therapeutic uses.
What does spermidine do?
Put simply, spermidine stimulates autophagy. The term “autophagy” comes from the Greek words “phagy” for “to eat” and “auto” for “self” and stands for a process that takes place in our body. When nutrients become scarce, cells can generate additional energy by recycling old or worn out, poorly functioning cell components. In addition to generating energy, this process renews the cell and makes it healthier.
Under normal conditions, autophagy in the body takes at least 24 hours fasting Set in motion. Should autophagy persist for a while, the fast would have to be continued for longer than 24 hours. Not only does this require a lot of discipline, fasting is unpleasant for most people. Spermidine, on the other hand, can stimulate autophagy without fasting for a long time or even by acting on the molecular signaling pathways that control aging.
While fasting causes the body to draw on its energy reserves to maintain the necessary processes, spermidine increases autophagy activity by stimulating the protein kinase mTORC1.
A study has shown that combining spermidine and fasting increases autophagy activity compared to fasting alone. These findings suggest that spermidine may help amplify the benefits of fasting by speeding up cell repair and detoxification.
But beyond that, spermidine has been shown to have several very specific effects.
Some studies suggest that it anti-inflammatory properties has and is involved in cell growth and proliferation as well as in programmed cell death, known as apoptosis, resulting in a reduced development of cancer can contribute. It has also shown that it can inhibit tumor growth and improve the survival of cancer patients. Spermidine also works by reducing lipid metabolism , which helps to regulate the life span.
Another benefit of spermidine is its ability to reduce the risk of cardiovascular diseases to reduce. Studies have shown that spermidine improves the effects of fasting on insulin sensitivity and helps reduce the risk of cardiovascular disease. It is thought that this is due to spermidine's ability to promote blood vessel formation and improve circulation.
Does taking spermidine actually extend life expectancy?
In a study published last year on mice, researchers wanted to find out how spermidine affects the organs that are usually most affected by the aging process. At the end of the study, they found that the mice treated with spermidine showed noticeable anti-aging effects, as opposed to mice of the same age that were not treated with spermidine. Thanks to spermidine treatment, the mice developed less kidney and liver damage in the experiment. The bald patches that typically occur in aging mice were also fewer in the mice treated with spermidine.
What impressed researchers the most was how spermidine helped to shorten the telomeres to decrease in heart tissue. Telomeres are the caps at the ends of chromosomes that protect DNA strands. In mice treated with spermidine, the telomeres were almost the same length as in younger mice. All of this research raises the question of whether taking spermidine actually extends people's life expectancy. Well, apparently it does.
Spermidine consumption
The good thing about spermidine is that it is found in plant foods, such as wheat germ, vegetable sprouts, mushrooms, peas, cauliflower, and broccoli. These foods all have a high spermidine content, but it is difficult to determine the exact spermidine content as the soil, cultivation and variety influence the polyamine content.
As the body's own production of spermidine in tissues or in our intestines decreases with increasing age, spermidine levels fall. Supplementing with spermidine supplements can be a way to consciously and specifically increase spermidine levels in the body.
The Austrian company Longevity Labs offers pure natural spermidine in the form of dietary supplements. They extract the active ingredient from GMO-free wheat germ from Central Europe and, according to Dave Asprey, it's the first permanent supplement he's found that meets his criteria for clean ingredients.
If you do not want to fast for health, time or personal reasons or do something good for your body even outside fasting periods, you can of course also implement the positive fasting effects of cell cleansing with a simple solution: with spermidineLIFE®. Together with zinc, it has a function in cell division, contributes to normal DNA and protein synthesis, and to protecting the cell from oxidative stress. spermidineLIFE® can increase cell repair and speed up cell cleansing without fasting.
Referenzen
- Fernández, L.F., Bárcena, C., Martínez-García, G.G., Tamargo-Gomez, I., Suárez, M.F., Pietrocola, F., Castoldi, F., Esteban, L., Sierra-Filardi, E., Boya, P., Lopez-Otín, C., Krömer, G. & Mariño, G. (2017). Autophagy couteracts weight gain, lipotoxicity and pancreatic β-cell death upon hypercaloric pro-diabetic regimens. Cell Death & Disease, 8(8), e2970—e2970. https://doi.org/10.1038/cddis.2017.373
- Levesque, S., Le Naour, J., Pietrocola, F., Paillet, J., Kremer, M., Castoldi, F., Baracco, E.E., Wang, Y., Vacchelli, E., Stoll, G., Jolly, A., De La Grange, P., Zitvogel, L., Krömer, G. & Pol, J.G. (2019). A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice. OncoImmunology, 8(11), e1657375. https://doi.org/10.1080/2162402x.2019.1657375
- Hofer, S.J., Davinelli, S., Bergmann, M., Scapagnini, G. & Madeo, F. (2021). Caloric Restriction Mimetics in Nutrition and Clinical Trials. Frontiers in Nutrition, 8. https://doi.org/10.3389/fnut.2021.717343
- Hofer, S.J., Carmona-Gutierrez, D., Müller, M.I. & Madeo, F. (2021). The ups and downs of caloric restriction and fasting: from molecular effects to clinical application. EMBO Molecular Medicine, 14(1). https://doi.org/10.15252/emmm.202114418
- Fan, J., Feng, Z. & Chen, N. (2020). Spermidine as a target for cancer therapy. Pharmacological Research, 159, 104943. https://doi.org/10.1016/j.phrs.2020.104943
- Singh, S., Kumar, R., Garg, G., Singh, A.K., Verma, A.K., Bissoyi, A. & Rizvi, S.I. (2020). Spermidine, a caloric restriction mimetic, provides neuroprotection against normal and d-galactose-induced oxidative stress and apoptosis through activation of autophagy in male rats during aging. Biogerontology, 22(1), 35—47. https://doi.org/10.1007/s10522-020-09900-z
- Soda, K. (2022). Overview of Polyamines as Nutrients for Human Healthy Long Life and Effect of Increased Polyamine Intake on DNA Methylation. Cells, 11(1) 164. https://doi.org/10.3390/cells11010164
- Schröder, S., Hofer, S.J., Zimmermann, A., Pechlaner, R., Dammbrück, C., Pendl, T., Marcello, G.M., Pogatschnigg, V., Bergmann, M., Gschiel, V., Ristic, S., Tadic, J., Iwata, K., Richter, G., Farzi, A., Üçal, M., Schäfer, U., Poglich, M.,. Madeo, F (2021). Dietary spermidine improves cognitive function. Cell Reports, 35(2), 108985. https://doi.org/10.1016/j.celrep.2021.108985
- Wirth, A., Wolf, B., Huang, C.K., Glage, S., Hofer, S.J., Bankstahl, M., Baer, C., Thum, T., Kahl, K.G., Sigrist, S.J., Madeo, F., Bankstahl, J.P. & Ponimaskin, E. (2021). Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length. GeroScience, 43(2), 673—690. https://doi.org/10.1007/s11357-020-00310-0
- Lumkwana, D., Peddie, C., Kriel, J., Michie, L.L., Heathcote, N., Collinson, L., Kinnear, C. & Loos, B. (2022). Investigating the Role of Spermidine in a Model System of Alzheimer's Disease Using Correlative Microscopy and Super-resolution Techniques. Frontiers in Cell and Developmental Biology, 10. https://doi.org/10.3389/fcell.2022.819571
Publiziert
17.3.2024
Kategorie
Lifestyle
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